I-5 itself continues northwest and meets the western end of SR 905, a route that connects with the Otay Mesa border crossing. Immediately after the border, I-805 splits off to the northeast and serves as a bypass of I-5 that avoids Downtown San Diego. I-5 begins at the San Ysidro Port of Entry from Mexico in the San Ysidro neighborhood of San Diego. I-5 is also eligible to be included in the State Scenic Highway System however, it is a scenic highway as designated by the California Department of Transportation (Caltrans) only from SR 152 to I-580. The segment of I-5 from State Route 89 (SR 89) to US 97 forms part of the Volcanic Legacy Scenic Byway, an All-American Road. I-5 is part of the California Freeway and Expressway System, and is part of the National Highway System, a network of highways that are considered essential to the country's economy, defense, and mobility by the Federal Highway Administration. Hilt (exit 796) is the last exit before the Oregon state line Montgomery Freeway, San Diego Freeway, Santa Ana Freeway, Golden State Freeway, and West Side Freeway. I-5 also has several named portions: the John J. I-5 is known colloquially as 'the 5' to Southern California residents and '5' to Northern California residents due to varieties in California English. The San Francisco Bay Area is about 80 miles (130 km) west of the highway. I-5 links the major California cities of San Diego, Santa Ana, Los Angeles, Stockton, Sacramento, and Redding. Route 101 (US 101), which is primarily coastal. It is the more important and most-used of the two major north–south routes on the Pacific Coast, the other being U.S. It is the longest interstate in California, and accounts for more than half of I-5's total length. The segment of I-5 in California runs 796.77 miles (1,282.28 km) across the length of the state from San Ysidro to the Oregon state line south of the Medford- Ashland metropolitan area.

Interstate 5 ( I-5) is a major north–south route of the Interstate Highway System in the United States, stretching from the Mexican border at the San Ysidro crossing to the Canadian border near Blaine, Washington. San Diego, Orange, Los Angeles, Kern, Kings, Fresno, Merced, Stanislaus, San Joaquin, Sacramento, Yolo, Colusa, Glenn, Tehama, Shasta, Siskiyou I-5 at the Oregon state line south of Ashland, OR

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